Abstract
The genetic control of resistance to two sterol biosynthesis inhibitors was investigated in the fungal pathogen Nectria haematococca. After UV light irradiation, resistant mutants were selected on either terbinafine, a squalene epoxidase inhibitor, or on fenpropimorph, an inhibitor of the sterol Δ 14 -reductase and/or Δ 8 →Δ 7 -isomerase. They were genetically characterized by random analysis of sexually produced ascospores. In seven induced mutants, terbinafine resistance resulted from mutations in a single gene (Ter1), leading to high resistance levels (...)
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