Abstract
ABSTRACTIn this work synthesis and characterization of inherently X-ray opaque, nonresorbable polyurethane microspheres with well-calibrated particles in a defined range of sizes suitable for embolization is reported. In order to impart X-ray opacity to the polyurethane, a bifunctional monomer, namely, 4,4′-isopropylidenediphenol (BPA) was iodinated and this iodinated compound was used as one of the monomers during polyurethane synthesis. The resultant X-ray opaque polyurethane was converted into microspheres using an oil-in-water emulsion and solvent evaporation technique. Microspheres obtained had diameters in the range of 200–500 µm, were noncytotoxic and free from X-ray attenuating additives. In vivo X-ray fluoroscopic imaging carried out in a rabbit cadaver model showed that these microspheres were sufficiently X-ray opaque to be visualized under fluoroscopic conditions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Polymeric Materials and Polymeric Biomaterials
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
