Abstract
AbstractStarting from an inherently chiral aminomethyl‐substituted resorcin[4]arene, a series of urea and amide derivatives were synthesized; these new functionalities extend the macrocycle cavity and introduce new opportunities for chiral recognition. A pair of diastereomeric macrocycles was obtained by introducing (S)‐(–)‐1‐phenylethyl‐urea functionalities. Chiral recognition capabilities of the diastereomeric hosts were investigated by circular dichroism spectral titration to reveal modest R/S selectivities of up to 1.4 for mandelic acid and other related carboxylic guests.
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