Abstract
Background. Despite current medical ad-vances, to this day there is no single medi-cal intervention to effectively prevent or treat bronchopulmonary dysplasia (BPD) in both preterm and term infants. Along with protective ventilation strategies, vari-ous drugs are being used or are being re-searched at this very moment, with the sole purpose of improving the general outcome for these patients. Inhaled dry salt micro particles therapy is now one of them. Materials and methods. This report pre-sents five patients, diagnosed with severe BPD. All of them received, complemen-tary to classical BPD management and respiratory support, continuous inhaled dry salt micro particles, via SaltMed car-tridges, for a period of 12 to 30 days. After only 24 hours of administration, we were able to observe a significant improvement in respiratory function and dynamics. It was possible to use a lower fraction of in-spired oxygen (FiO2), mean airway pres-sure (MAP) and peak inspiratory pressure (PIP) in all mechanically ventilated pa-tients. Higher tidal volumes were recorded and we observed improvement in oxygen-ation indexes.Conclusion. Continuously inhaled dry salt micro particles, administered complemen-tary to classic BPD management, could improve respiratory and overall morbid-ity and mortality in infants with any form of BPD. Further study of these possible effects is needed, as there is no data pub-lished on this matter so far.
Highlights
Bronchopulmonary dysplasia (BPD) remains one of the leading causes for chronic pulmonary disease, in mostly preterm, and term neonates, that requires prolonged administration of supplemental oxygen and mechanical ventilation
(2) A study published by the United States National Institute of Child Health and Human Development (NICHHD), [3] established that the incidence of bronchopulmonary dysplasia (BPD) rises with a decrease in gestational age, with 85 % of the gestational week infants being affected, in comparison to % among those born at 28 weeks of gestational age
We found that administration of hypertonic saline solution (3%) could decrease the hyperreactivity of bronchioles, which is sometimes associated with BPD
Summary
Bronchopulmonary dysplasia (BPD) remains one of the leading causes for chronic pulmonary disease, in mostly preterm, and term neonates, that requires prolonged administration of supplemental oxygen and mechanical ventilation. In this paper we would like to present data obtained after administering inhaled dry salt micro particles, via SaltMed cartridges (produced by Tehno Bionic, Romania), to five patients diagnosed with severe BPD, as a complementary intervention in their medical management. To this day there is no published data regarding this kind of therapy in the management of BPD. The forced passage of air through a specially designed dry salt SaltMed cartridge (figure 1) containing salt microcrystals, produces erosion to a state of micro particles of dry sodium chloride Their size ranges from 1 to 5 micrometers. The manufacturer reports that immediate effects of inhaled dry salt micro particles are as follows: increase in quantity of secretions in the upper and lower arespiratory tract, rhinorrhea and sputum, activation of airway cilia and rapid clearance of secretions
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