Abstract
BackgroundThere is considerable evidence from the literature that children with chronic lung disease of infancy (CLD) have abnormal pulmonary function in childhood and this could have an impact on their life quality and overall health. There are similarities between CLD and asthma, and corticosteroids are the mainstay treatment for asthma. Many physicians use inhaled corticosteroids in children with CLD with no evidence. Therefore we wish to conduct a randomized double-blinded placebo controlled trial to test for the role of inhaled corticosteroids in children aged from3 to 9 years with a history of CLD. Our primary hypothesis will be that inhaled corticosteroids are beneficial in children with CLD.MethodsOur primary hypothesis is that using inhaled steroids; Beclomethasone Dipropionate (QVAR) 100 mcg 2 puffs 2 times a day for 6 weeks will improve the respiratory system resistance and the quality of life in children with CLD.DiscussionWe propose that Beclomethasone Dipropionate (QVAR) will affect the pulmonary function after 6 weeks of treatment. In summary we think that our study will highlight knowledge on whether the use of inhaled steroids is clinically effective for CLD.
Highlights
There is considerable evidence from the literature that children with chronic lung disease of infancy (CLD) have abnormal pulmonary function in childhood and this could have an impact on their life quality and overall health
It was documented that prematurely born children with respiratory distress syndrome (RDS) have long term pulmonary sequelae consisting of airway obstruction and airway hyper reactivity, which are related to both the severity of the initial pulmonary insult and its treatment as well as to a familial predisposition to airway hyper reactivity
BMC Pulmonary Medicine 2005, 5:6 http://www.biomedcentral.com/1471-2466/5/6 role of inhaled corticosteroids in children with chronic lung disease of infancy or bronchopulmonary dysplasia was not previously studied most if not all physicians use this treatment for these children whenever they develop chest infections or wheezy episodes
Summary
There is considerable evidence from the literature that children with chronic lung disease of infancy (CLD) have abnormal pulmonary function in childhood and this could have an impact on their life quality and overall health. BMC Pulmonary Medicine 2005, 5:6 http://www.biomedcentral.com/1471-2466/5/6 role of inhaled corticosteroids in children with chronic lung disease of infancy or bronchopulmonary dysplasia was not previously studied most if not all physicians use this treatment for these children whenever they develop chest infections or wheezy episodes. This is a randomized double blinded placebo controlled study using inhaled corticosteroid (CFC free Beclomethasone dipropionate, QVAR) for 6 weeks and measuring the effect on pulmonary function and quality of life
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