Abstract
Groups of 50 male and 50 female Syrian golden hamsters were exposed to talc aerosol for 3, 30 or 150min/day, 5 days/wk for 30 days, or for 30 or 150min/day either until they died naturally or for a maximum of 300 days. The mean concentration of the ‘respirable’ aerosol fraction was approximately 8 μg/litre and the mass mean aerodynamic diameter was 6 μm. Following the exposures, the animals were observed for the remainder of their lifespan. At death, lungs trachea, larynx, liver, one kidney, stomach, uterus, one ovary, or one testis, and all tissues showing gross lesions were collected for histopathological examination. Deposition of talc particles in the lungs of the exposed animals was demonstrated by X-ray fluorescence and by X-ray diffraction. The exposures to talc aerosol had no effect on body weight, survival or the type, incidence or degree of histopathological change in the exposed groups compared with sham-exposed controls.
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