Inhalation Delivery of Therapeutic Peptides and Proteins

Abstract

The Human Respiratory Tract: Biophysical Issues in Peptide Drug Delivery, Pramod K. Gupta Physiological and Biomechanical Factors Relevant to Inhaled Drug Delivery, Chong S. Kim and Lawrence J. Folinsbee Biophysics of Inhaled Drug Particles, Ananth Annapragada, Paul Swanson, and Fernando Muzzio Chemical and Physical Properties of Peptide and Protein Drugs, William R. Porter Absorption and Bioavailability of Inhaled Peptides and Proteins, Yihong Qiu, Pramod K. Gupta, and Akwete Lex Adjei The Human Respiratory Tract: Pharmaceutical Issues in Peptide Drug Delivery, Akwete Lex Adjei Intranasal Delivery of Peptides and Proteins, Lisbeth Illum and Anthony Neil Fisher Therapeutic Inhalation Aerosols, Pramod K. Gupta and Akwete Lex Adjei Generation and Characterization of Aerosols for Drug Delivery to the Lungs, Cecily B. Lalor and Anthony J. Hickey Localized Delivery of Peptides and Proteins to the Lung: Case Studies, Akwete Lex Adjei Cyclosporine, Gilbert J. Burckart, Robert Keenan, Bartley P. Griffith, and Aldo T. Iacono Inhalational Interferon, Nico van Zandwijk Alpha-1 Antitrypsin, Richard C. Hubbard Aerosol Delivery of Alpha1 Proteinase Inhibitor: A Paradigm for Delivery of Therapeutic Proteins to the Lung, Robert M. Smith Deoxyribonuclease Inhalation, Igor Gonda Systemic Delivery of Peptides and Proteins by Inhalation: Case Studies, Akwete Lex Adjei and Pramod K. Gupta Insulin Inhalation: Its Potential as a Nonparenteral Method of Administration, Stephen J. Farr and Glyn Taylor LH-RH Analongs, Akwete Lex Adjei and Mou-ying Fu Lu Feasibility Studies with Recombinant Human Granulocyte Colony-Stimulating Factor, Ralph W. Niven Inhalation Therapy for Growth Hormone Deficiency, Doris A. Wall and Philip L. Smith Gene Delivery and Transfer via the Lung, Akwete Lex Adjei General Issues in Gene Delivery via the Lung, Marsha M. Thompson and Jeanine P. Wiener-Kronish Inhalation Delivery and Formulation Issues in Gene Therapy in the Respiratory Tract, Thomas W. Patapoff and Igor Gonda Gene Therapy for Lung Disease: Molecular and Clinical Therapeutic Issues, Larry G. Johnson and Richard C. Boucher The Cell Biology of Gene Therapy for Cystic Fibrosis, Kenneth Crook and David J. Porteous Alternate Technologies in Pulmonary Delivery, Akwete Lex Adjei and Pramod K. Gupta Non-Ozone-Depleting Propellants, Pramod K. Gupta and Akwete Lex Adjei Dry Powder Inhalation Aerosols, Akwete Lex Adjei and Pramod K. Gupta Modulated-Release Aerosol, Pramod K. Gupta and Akwete Lex Adjei Novel Aerosol Peptide Drug Delivery Systems, Reid Rubsamen Guidelines for Development of Aerosolized Peptides, Akwete Lex Adjei Developmental Pharmaceutics of Inhaled Peptides and Proteins, Akwete Lex Adjei and Pramod K. Gupta Clinical Development of Inhaled Peptides and Proteins, Akwete Lex Adjei Key Worldwide Patents on Pulmonary Drug Delivery, Pramod K. Gupta Key Worldwide Patents in Pulmonary Drug Delivery, Pramod K. Gupta and Akwete Lex Adjei