Abstract
Abstract The postprandial blood glucose and hormonal responses to isomalto-oligosaccharides (IMO) are unclear. The objective of this study was to compare postprandial glucose, insulin and incretin responses of IMO with dextrose in healthy adults. In trial 1, blood glucose responses to IMO, isomaltose, dextran and maltodextrin were compared with dextrose in n = 12 participants. In trial 2, serial glucose and hormone measurements over 2 h were measured in n = 10 participants. The glycemic effect of IMO was calculated using the Glycemic Glucose Equivalents (GGE) and Relative Glycemic Index (RGI). IMO exhibited a hyperglycemic effect compared to dextrose as indicated by a GGE of 1.35 g and an RGI of 27.0 g. The responses to IMO of both active GLP-1 and GIP were similar to that of dextrose. The paradoxical hyperglycemic response despite robust insulin and incretin secretion requires further investigation.
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