Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults

Jiro Takeo,Zhi-Hong Yang,Hiroko Miyahara,Masashi Katayama

doi:10.1186/1476-511x-11-95

Abstract

BackgroundSaury oil contains considerable amounts of n-3 polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) with long aliphatic tails (>18C atoms). Ingestion of saury oil reduces the risk of developing metabolic syndrome concomitant with increases in n-3 PUFA and long-chain MUFA in plasma and organs of mice. We therefore evaluated changes in postprandial plasma fatty acid levels and plasma parameters in healthy human subjects after ingestion of a single meal of saury.FindingsFive healthy human adults ingested 150 g of grilled saury. Blood was collected before the meal and at 2, 6, and 24 hr after the meal, and plasma was prepared. Plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and long-chain MUFA (C20:1 and C22:1 isomers combined) increased significantly throughout the postprandial period compared with the pre-meal baseline. Postprandial plasma insulin concentration increased notably, and plasma levels of glucose and free fatty acids decreased significantly and subsequently returned to the pre-meal levels.ConclusionsOur study suggests that a single saury meal may alter the postprandial plasma levels of n-3 PUFA and long-chain MUFA in healthy human subjects.

Highlights

Saury oil contains considerable amounts of n-3 polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) with long aliphatic tails (>18C atoms)
Our study suggests that a single saury meal may alter the postprandial plasma levels of n-3 PUFA and long-chain MUFA in healthy human subjects
We previously reported that a fish oil–derived concentrate containing long-chain monounsaturated fatty acids (MUFA), i.e., C20:1 and C22:1 isomers combined, alleviated metabolic syndrome partly by regulating genes involved in lipid metabolism, energy expenditure, and

Summary

Background

Increasing evidence from animal and human experiments has demonstrated that two particular long-chain n-3 polyunsaturated fatty acids (PUFA), i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been associated with multiple positive health effects including improvement of obesity and diabetes mellitus [1], cardiovascular and neurodegenerative diseases [2,3], asthma [4], and inflammatory diseases [5]. We investigated changes in plasma levels of EPA, DHA, and long-chain MUFA after ingestion of a single meal of saury. To our knowledge, this is the first report evaluating the effect of a single ingestion of saury on postprandial fatty acid composition and in plasma of healthy human subjects

Methods

Results and discussion

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