Abstract
Technologies capable of noninvasively sampling different locations in the gut upstream of the colon enable new insights into the role of organ‐specific microbiota in human health. Herein, an ingestible, biocompatible, battery‐less, 3D‐printed microengineered pill with an integrated osmotic sampler and microfluidic channels for in vivo sampling of the gut lumen and its microbiome upstream of the colon is discussed. The pill's sampling performance is characterized using realistic in vitro models and validated in vivo in pigs and primates. Herein, the results show that the bacterial populations recovered from the pill's microfluidic channels closely resemble the bacterial population demographics of the microenvironment to which the pill is exposed. Herein, it is believed that such lab‐on‐a‐pill devices revolutionize the understanding of the spatial diversity of the gut microbiome and its response to medical conditions and treatments.
Highlights
Samples important for understanding the interaction between enteric pathogens and the host remain out of reach, The gut microbiota represents trillions of bacteria belonging to unless invasive sampling techniques are used.[11]
Among the various microbial communities insights into the many beneficial functions of the gut microbiota, associated with the human body, the gut microbiome is noted for it is essential to sample in vivo different locations in the gut, parits diversity, elevated concentration,[2,3] and many beneficial func- ticularly organs located upstream of the colon
The head comprises four inlets, a stilling basin connected to four helical channels, all of them leading to one small chamber
Summary
Samples important for understanding the interaction between enteric pathogens and the host remain out of reach, The gut microbiota represents trillions of bacteria belonging to unless invasive sampling techniques are used.[11] To gain new around 1000 species.[1] Among the various microbial communities insights into the many beneficial functions of the gut microbiota, associated with the human body, the gut microbiome is noted for it is essential to sample in vivo different locations in the gut, parits diversity, elevated concentration,[2,3] and many beneficial func- ticularly organs located upstream of the colon. Dysbiosis (microbial imbalance) has been associated with. We describe the development and testing of an innovaconditions such as inflammation, recurrent infections, and tive noninvasive technology to sample the intestinal lumen in. Sonkusale Nano Lab, Advanced Technology Laboratory Tufts University 200 Boston Avenue, Medford, MA 02155, USA
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