Abstract
The antithrombotic effect of prostacyclin infusion on severely traumatized vessels has been evaluated. A group of 3 rabbits was used to establish a prostacyclin dose which produced platelet antiaggregating effects without significantly affecting blood pressure. Twenty-seven central arteries of rabbit ears were prepared and 32P-labelled platelets infused. Arteriotomy (7 mm)/intimectomy (5 mm) were performed and in vivo platelet accumulation followed for 2 h. Fifteen of the vessels served as control. Bleeding times, platelet accumulation, patency and deposits of thrombus material were recorded. Following prostacyclin infusion bleeding times were significantly prolonged, patency significantly improved and platelet accumulation somewhat lower than in the control group. Prostacyclin thus has an antithrombotic effect but due to its other properties is complicated to use clinically.
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