Infrared spectroscopy of liposomes obtained by different variants of the injection method

Abstract

The study by infrared spectroscopy of the structure of liposomes used in veterinary medicine as nanocontainers for the targeted delivery of medicinal substances to the cells of body tissues is a very important area of research. In the process of obtaining liposomes and liposomal preparations, processes of phospholipid modification occur. At present, the method of IR spectroscopy is used to control the deposition of substances on the surface of a liposome in order to study the delivery of drugs, etc. The comparative study of liposomes obtained by different versions of the injection method was first carried out by infrared spectroscopy. According to the results of medium-wave spectroscopy, the peaks of absorption of IR radiation in various wavelength ranges for these liposomes were revealed. This indicates the presence in liposomes of groups of atoms -CH3, -CH2-, primary and secondary alcohols, cis- and trans-isomers HRC = CR´H, groups –OH, groups C=O, solid fatty acids. The results of the study can be used as reference identification IR spectra for the express identification of liposomes obtained by the injection method, and the use of the Fourier IR spectroscopy method for studying the structure of liposomes with encapsulated potassium orotate can be of wide practical importance as a method of express analysis.