Abstract
Application of monoisotopic cationic 109Ag nanoparticles (109AgNPs) obtained by PFL (pulsed fiber laser) 2D GS (galvo-scanner) LASiS (laser ablation synthesis in solution) for high resolution laser desorption/ionization mass spectrometry and mass spectrometry imaging of carboxylic acids is presented. Six acids, azelaic, 3-methylhippuric, linoleic, oleic, arachidic and erucic acid were used as test compounds for quantification with a MALDI-type mass spectrometer. Comparison of commonly made manual measurements with semi-automatic MSI was performed providing very interesting findings. Carboxylic acids were directly tested in 1 000 000-fold concentration change conditions ranging from 1 mg/mL to 1 ng/mL, which equates to 300 ng to 300 fg of carboxylic acid per measurement spot. Methods were also tested on samples of spiked human blood serum for quantification of carboxylic acids and verification of the influence of biological matrix on the measurement.
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