Abstract
In this study, we coated poly-lactic acid(PLA)-tetracycline complexes to the surface of gold nanorod incorporated titania nanotubes with different concentration (0.1 - 1.0 wt%) of PLA-tetracycline complexes and estimated their infrared LASER mediated antibacterial effect and biocompatibility. The results of Transmission electron microscopy(TEM) and UV-Vis spectrophotometer indicated that gold nanorods had the 1 to 4 of aspect ratio and showed the highest absorbance at the wavelength of 800 nm. Energy Dispersive X-ray Spectrometer(EDX) analysis showed that the amounts of gold nanorods coated on titania nanotubes were approximately 8 wt%. MTT assay resulted that the cell viability of all experimental groups were significantly higher than 70% (minimum requirement of biocompatibility) after 24 and 48 hrs of incubation times. Antibacterial test resulted that all experimental groups showed antibacterial activity against Streptococcus mutans regardless of the concentration of PLA-tetracycline complexes, and the annihilation of Streptococcus mutans were accelerated by infrared LASER irradiation. Therefore, infrared LASER mediated antibacterial activity of gold nanorods is expected to be more effective in the field of implant fabrication due to the invisible antibacterial effect of gold nanorods via infrared LASER irradiation.
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