Abstract
Utilizing a combination of time-resolved Infrared (IR) spectroscopies, we are able to probe the effects of a small biological molecule (cholesterol) on the dynamics of lipid membranes from picoseconds to milliseconds. By monitoring the ultrafast dynamics of the system with multi-dimensional IR spectroscopy, we are able to resolve the influence cholesterol has on the electric field fluctuations inside the membrane. We use temperature-jump (T-jump) spectroscopy to extend our experimentally-observable time window beyond the vibrational lifetime of our probe and find that the presence of cholesterol introduces significant inhomogeneity into the relaxation rates of the system. This approach provides new insight into the interaction between cholesterol and lipids, while also demonstrating the utility of this combined IR spectroscopic toolbox for studying multiscale dynamics.
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