Infralimbic/anterior cingulate/amygdala projections to the gastrointestinal preganglionic vagal neurons in the medulla

Abstract

Event Abstract Back to Event Infralimbic/anterior cingulate/amygdala projections to the gastrointestinal preganglionic vagal neurons in the medulla Éva Rebeka Szabó1*, Aniko Reichart1, Rege Sugárka Papp1 and Miklos Palkovits1 1 Department of Anatomy, Histology and Embryology, Semmelweis University, Hungary The possible role of the medial prefrontal cortex (mPFC) in the regulation of gastric activity has been suggested, and direct (monosynaptic) and indirect (multisynaptic) projections from the prefrontal cortex have been documented to the gastrointestinal projecting preganglionic neurons in the dorsal motor vagal nucleus in the dorsomedial medulla. Signals from prelimbic, infralimbic and dorsal peduncular cortical neurons may be relayed by hypothalamic or amygdaloid neurons. In our previous study, by using pseudorabies virus, a retrograde multisynaptic tracer, the existence of axonal projections from all of the compartments of the mPFC to the central amygdala (CeA) has been proved. The fine topography of an infralimbic – anterior cingulate – central amygdala neuronal circuit was investigated in the present study. To localize the individual compartment of this neuronal circuit biotinylated dextran amine (BDA) was deployed into the anterior cingulate cortex (ACi) and the infralimbic cortex, separately. Bilateral and unilateral surgicals transections through the caudal portion of the ACi, and BDA administrations into the ACi and the infralimbic cortex lead to identify one of the possible routes from the mPFC to the CeA. In intact rats, unilateral labeling was seen in the anterior amygdaloid area, the basolateral amygdala, and in the basolateral intercalate cells close to the CeA. Along the external capsule, BDA-labeled fibers were followed from the ACi into the amygdala. These fibers were eliminated by the surgical transections. Although, retrograde viral labeling suggested a direct anterior cingulate – central amygdala connections, the monosynaptic BDA tracing indicated the existence an intraamygdaloid (basolateral – central amygdala) relay of the prefrontal projections by GABAergic intercalate neurons. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Developmental neurobiology and subcortical functions Citation: Szabó É, Reichart A, Papp R and Palkovits M (2009). Infralimbic/anterior cingulate/amygdala projections to the gastrointestinal preganglionic vagal neurons in the medulla. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.078 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 02 Mar 2009; Published Online: 02 Mar 2009. * Correspondence: Éva Rebeka Szabó, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary, szabo.eva.rebeka@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Éva Rebeka Szabó Aniko Reichart Rege Sugárka Papp Miklos Palkovits Google Éva Rebeka Szabó Aniko Reichart Rege Sugárka Papp Miklos Palkovits Google Scholar Éva Rebeka Szabó Aniko Reichart Rege Sugárka Papp Miklos Palkovits PubMed Éva Rebeka Szabó Aniko Reichart Rege Sugárka Papp Miklos Palkovits Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.