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Abstract
Selective antagonists of either the D 1 receptor (SCH 23390) or of the D 2 receptor (raclopride) produce a dose-related inhibition of sucrose sham feeding in the rat. We investigated the effect of combined treatments with these antagonists on sucrose sham feeding and observed infra-additivity of inhibition across a range of doses. On the basis of this observed occlusive relationship, we conclude that the relevant D 1 and D 2 receptor mechanisms mediating sweet taste reward do not function independently.
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