Abstract
The problem of informed consent in clinical research involving demented patients is more and more vexed. Together with an historical review of the most authoritative international statements taken since Nuremberg till today, the document on this topic recently published in the Italian Journal of Neurological Sciences and prepared by members of the Bioethics and Neurology Working Group of the Italian Society of Neurology (including the author) is further commented. The critique on distinction between therapeutic and non-therapeutic research and the recommendations of the Group in relation to the different phases of pharmacological research are among the subjects dealt with.
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