Abstract
Total cell RNA purified from cultured mouse cells induced to synthesize interferon causes mouse interferon synthesis in heterospecific cell cultures. Metabolic and physicochemical criteria support the conclusion that genetic information is transferred as the messenger RNA (mRNA) for mouse interferon. The species specificity and physicochemical properties of the product suggest that it is mouse interferon. These results confirm the report by De Maeyer, De Maeyer-Guignard and Montagnier (Proc. Natl. Acad. Sci., 69, 1203 (1972)). By means of RNA transfer, we have devised a relative quantitative assay for interferon mRNA activity. Because the biological activity of the mRNA can be assayed, new opportunities exist for the study of the control of a specified gene and the metabolism of a specific messenger RNA.
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