Abstract
Regional Pharmacovigilance Centres (RPC), created in 1972, now number 30. Since May 1984, they have had a threefold function: (1) collecting and evaluating unexpected or toxic effects of drugs, (2) disseminating information regarding drugs, and (3) research. In 1988, the annual number of validated Adverse Drug Reactions (ADRs) was in excess of 10,000, that of queries was nearly 20,000, and that of overdoses still far higher.Queries may be broken down into pharmacological advice, concerning a specific patient, general information about drugs, ADRs transmitted to another RPC closer to the patient, ADRs not clearly identified by the notifying physician, and ADRs recognized as such later on. Pharmacological advice may be requested before or after the drug intake. It mainly concerns pregnancy, breast feeding, drug interactions, and pharmacogenetic problems. The origin of queries and ADRs is essentially physicians (89.5%). The information activity of RPC includes organizing meetings, scientific articles (eg, ne...
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