Information Theory Based Analysis for Understanding the Regulation of HLA Gene Expression in Human Leukemia

Abstract

Considering information entropy (IE), HLA surface expression (SE) regulation phenomenon is considered as information propagation channel with an amount of distortion. HLA gene SE is considered as sink regulated by the inducible transcription factors (TFs) (source). Previous work with a certain number of bin size, IEs for source and receiver is computed and computation of mutual information characterizes the dependencies of HLA gene SE on some certain TFs in different cells types of hematopoietic system under the condition of leukemia. Though in recent time information theory is utilized for different biological knowledge generation and different rules are available in those specific domains of biomedical areas; however, no such attempt is made regarding gene expression regulation, hence no such rule is available. In this work, IE calculation with varying bin size considering the number of bins is approximately half of the sample size of an attribute also confirms the previous inferences.