Abstract

Despite of arterial hypertension high prevalence and its complications in Mongolia, the epidemiology and structure of hypertension-mediated organ damage remains insufficiently studied. Aim. To assess elaboration level of the problem of AH-associated hypertension-mediated organ damage in Mongolia. Materials and methods. Leading international guidelines and recommendations, reviews, meta-analyzes, randomized controlled, population-based research and Mongolian scientific papers with different evidential value, related to hypertension-mediated organ damage were analyzed. Results and discussion. In developed countries, hypertension-mediated organ damage structure and their contribution to total cardiovascular risk stratification in patients with hypertension is well studied. In 2018 ESC/ESH Guidelines for the management of arterial hypertension hypertension-mediated organ damage criteria were only slightly extended. Data on arterial hypertension epidemiology, including hypertension-mediated organ damage structure, in Mongolian population, mainly obtained from ethnic Mongols living in the territory of Inner Mongolia and other provinces of China, or in international studies with Mongolia participation. Directly in Mongolia, hypertension-mediated organ damage were studied in small samples; a systemic epidemiological analysis of hypertension-mediated organ damage was not carried out. Conclusions. Given arterial hypertension significance in Mongolia and insufficient scientific elaboration of problem, population studies are needed to clarify hypertension-mediated organ damage prevalence and structure in order for improving arterial hypertension management.

Highlights

  • Data on arterial hypertension epidemiology, including hypertension-mediated organ damage structure, in Mongolian population, mainly obtained from ethnic Mongols living in the territory of Inner Mongolia and other provinces of China, or in international studies with Mongolia participation

  • In Mongolia, hypertension-mediated organ damage were studied in small samples; a systemic epidemiological analysis of hypertension-mediated organ damage was not carried out

  • INFORMATION ABOUT SCIENTIFIC STUDDING LEVEL ON PROBLEM OF HYPERTENSION MEDIATED ORGAN DAMAGE

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Summary

АСИМПТОМАТИЧЕСКОЕ ПОРАЖЕНИЕ ОРГАНОВ МИШЕНЕЙ

ЭКГ признаки ГЛЖ: — Индекс Соколова—Лайона > 38 мм — R (аVL) 11 мм — Корнельское произведение > 2440 мм ⋅ мс — Корнельский вольтажный индекс > 28 мм у М и > 20 мм у Ж ЭХО КГ признаки ГЛЖ: — ММЛЖ (г/м2 ППТ) ≥ 125 у М и ≥ 110 у Ж. — Индекс ММЛЖ (г/м2,7) > 50 у М и > 47 у Ж ЭХО КГ признаки утолщения сонных артерий с толщиной КИМ ≥ 0,9 мм или наличие бляшки Умеренное повышение креатинина у М от 115 до 133 (1,3—1,5) и у Ж от 107—124 (1,2—1,4) мм/л (мг/дл) МАУ: 30—300 мг/24 ч; АКО у М ≥ 22 (2,5) и у Ж ≥ 31 (3,5) мг/г (мг/ммоль) ЛПИ < 9 СКФПВ > 12 м/с ПД ≥ 60 мм рт. — Индекс ММЛЖ (г/м2,7) > 50 у М и > 47 у Ж ЭХО КГ признаки утолщения сонных артерий с толщиной КИМ ≥ 0,9 мм или наличие бляшки Умеренное повышение креатинина у М от 115 до 133 (1,3—1,5) и у Ж от 107—124 (1,2—1,4) мм/л (мг/дл) МАУ: 30—300 мг/24 ч; АКО у М ≥ 22 (2,5) и у Ж ≥ 31 (3,5) мг/г (мг/ммоль) ЛПИ < 9 СКФПВ > 12 м/с ПД ≥ 60 мм рт. ст. у пожилых лиц ХБП с рСКФ < 60 мл/мин/1,73 м2 ППТ (MDRD) или < 60 мл/мин (Gault Cockroft) Осложненная ретинопатия (геморрагическая или экссуда тивная), отек соска зрительного нерва

Диабетическая нефропатия
Years of releasing of European guidelines for AH
ASYMPTOMATIC DAMAGE OF TARGET ORGANS
Atherosclerotic damage of peripheral arteries
БИБЛИОГРАФИЧЕСКИЙ СПИСОК
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