Abstract
BackgroundMultidrug-resistant organisms (MDRO) are a worldwide problem. International migration and travel facilitate the spread of MDRO. Therefore the goal of our study was to assess the risk of influx of MDRO from patients transferred to one of Central Europe’s largest hospitals from abroad.MethodsA mono-centre study was conducted. All patients transferred from other countries were screened; additional data was collected on comorbidities, etc. Presence of carbapenemases of multidrug-resistant Gram-negatives was confirmed by PCR. The association between length of stay, being colonized and/or infected by a MDRO, country of origin, diagnosis and other factors was assessed by binomial regression analyses.ResultsFrom 2012 to 2013, one fifth of all patients were colonized with MDRO (Methicillin-resistant Staphylococcus aureus [4.1 %], Vancomycin-resistant Enterococci [2.9 %], multidrug-resistant Gram-negatives [12.8 %] and extensively drug-resistant Gram-negatives [3.4 %]). The Gram-negatives carried a variety of carbapenemases including OXA, VIM, KPC and NDM. The length of stay was significantly prolonged by 77.2 % in patients colonized with a MDRO, compared to those not colonized (p<0.0001).ConclusionsCountry-to-Country transfer of patients to European hospitals represents a high risk of introduction of MDRO and infection control specialists should endorse containment and screening measures.
Highlights
Multidrug-resistant organisms (MDRO) are a worldwide problem
Microbiological results Eighty-seven of 414 patients were colonized with MDRO
The proportion of colonization, compared to patients from other hospitals in Germany, was equal with regards to vancomycin-resistant Enterococci (VRE) (2.9 % vs. 2.9 %), while it was superior with regards to all other MDROs [Methicillin-resistant Staphylococcus aureus (MRSA) (4.1 % vs. 2.4 %), multidrugresistant Gram-negatives (MDR-GN) (12.8 % vs. 2.2 %), Extensively drug-resistant Gram-negatives (XDR-GN) (3.4 % vs. 0.3 %)]
Summary
Multidrug-resistant organisms (MDRO) are a worldwide problem. Multidrug-resistant organisms (MDRO) are a worldwide problem and the speed at which resistance rates are increasing is worrying. Antibiotic resistance crosses international boundaries and spreads between continents [1]. Surveillance systems such as the European Antimicrobial Resistance Surveillance System network report a continuing increase in antimicrobial resistance. International travel and patient transfers from hospitals located in high-prevalence regions to hospitals in low-prevalence regions facilitate the spread of MDRO. This condition triggers the introduction and establishment of MDRO into previously unaffected or less affected regions [2]. Methicillin-resistant Staphylococcus aureus (MRSA), for example, is a major cause of
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