Abstract
Selenium is an essential dietary trace element and its deficiency can cause some pathologies such as cardiac diseases. However, investigations have evidencied the toxicologic effect of organic and inorganic selenium compounds in the organs and enzymes.The present work examined the toxic effect of selenium on δ-ALA-D an enzyme involved in the biosynthesis of tetrapyrrol heme. A possible protective role of zinc on inhibitory effect of selenium was also evaluated. The organic selenium compound, (CH3)2C (Seφ) (0CH3) caused a dose dependent inhibition of renal, hepatic and cerebral δ-ALA-D (p< 0.01). Also was evidencied that the selenium and zinc interaction not was able to restore the δ-ALA-D activity inhibited by selenium but increasing the inhibitory effect from the compound on the renal and cerebral enzyme.
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