Abstract

The healing activity of the hydroethanolic extract of Tropaeolum majus leaves on rats´ skin lesions is provided. Fifteen Wistar rats were used, distributed in three groups, G7, G14 and G21, according to observation period 7, 14 and 21 days after surgery. Two wounds, diameter 1 cm, on the dorsal region of each animal, were treated with Carbopol gel on the left side and by Tropaeolum majus on the right side. Lesions were treated daily during the periods above. A comparative study was undertaken between the two groups by micro- and macroscopy. The formation of a wound scab on all wounds up to the seventh day was observed. Histological assessment revealed that lesions treated with Tropaeolum majus extract had a lower inflammatory infiltrate rate and fibroblastic proliferation when compared to lesions treated with gel, coupled to a greater collagenization and deeper angiogenesis on the 7th, 14th and 21st day after surgery. Results showed that hydroethanolic extract of Tropaeolum majus leaves caused a better improvement in the healing process through the increase in the formation of neo-vases and collagenization.

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