Abstract
To evaluate the influence of cholestatic jaundice in weight variation. We used 64 adult rats divided into six groups: F1 (n = 6): normal females; F2 (n = 6): laparotomy females; F3 (n = 20): jaundiced females; M1 (n = 6): normal males; M2 (n = 6): laparotomy males; M3 (n = 20): jaundiced males. Jaundice was obtained by ligation and section of the biliopancreatic duct. The animal weights were recorded weekly for seven weeks. On the 14th day of the experiment, bilirubin and gonadal hormones were assessed. After the seventh week a histological study of the liver was performed. The animals in groups F3 and M3 showed elevated bilirubin and decreased body mass when compared to the other groups. The weight differences were significant from the fourth week on amongst females and from the fifth in males. In Jaundiced animals there was increased estradiol and decreased progesterone and testosterone. Perivenular septa and periportal fibrosis, cholangitis and bile duct hyperplasia occurred in the liver of jaundiced rats. No animal showed cirrhosis. There was decrease in murine body weight in the presence of cholestatic jaundice in both genders.
Highlights
Jaundice is the clinical manifestation of many liver and non-liver diseases, reflecting disruptions in production, metabolism and excretion of bilirubin
While there are discussions about possible effects of hyperbilirubinemia in body metabolism, there are still studies that examine the impact of liver disease on body weight 25
Given the importance of risk factors caused by hyperbilirubinemia and their relations to body weight, the present study aimed to evaluate the influence of cholestatic jaundice in weight variation
Summary
Jaundice is the clinical manifestation of many liver and non-liver diseases, reflecting disruptions in production, metabolism and excretion of bilirubin. While there are discussions about possible effects of hyperbilirubinemia in body metabolism, there are still studies that examine the impact of liver disease on body weight 25. In 2004, studied 219 candidates to liver transplant of both genders and observed that patients with cholestatic diseases were more malnourished when compared to patients with non-cholestatic diseases[6]. Other authors suggested interaction between hepatic metabolism and body mass[7,8,9]. Given the possibility of distinct liver characteristics between genders of the same species and the close relationship between the metabolism of sex steroids and liver function, body mass should be considered when studying cholestatic jaundice[1,4,11]
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