Influnce of Pregnancy on Women's Platelet Antibody

Abstract

Objective To explore the influence of pregnancy on women's platelet (PLT) antibody.Methods Research objects were divided into the observation group and control group.The members in the observation group were 291 pregnant women who received the prenatal examination in the blood group reference laboratory of Liaocheng Blood Center from February 2009 to December 2011.The members in the control group were 4613 healthy female blood donors donated blood in our station during the same period.Blood samples of observation group were collected when the pregnant women were pregnant in the 16th,20th,24th,28th,30th,32nd,34th and 36th week.Blood samples of control group were collected when they donated blood.Apply simplified sensitized erythrocyte platelet serology assay (SEPSA) method and randomly take 5 samples of mixed platelets of type O blood to test platelet antibody.The Yantai Haimo New Generation of Blood Safety and Service System was adopted for data processing and χ2 inspection was adopted for statistical analysis (The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Liaocheng Blood Center). Results In the observation group, PLT antibody positive rate was 20.5％ (45/219).PLT antibody positive rate increased with the increase of the number of pregnancy (χ2=16.409,P＜0.05).During the 16 to 28 weeks of pregnancy,the positive rate increased with the increase of the time of pregnancy (χ2 =16.082,P＜0.05).But during the 28 to 36 weeks of pregnancy,the difference of positive rate was not statistically significant (χ2 =0.054,P＞0.05). Incontrol group,there were 131 positive cases and 4482 negative cases.Positive rate of women who had pregnancy history were higher than who had no pregnancy history (χ2 =134.676,P＜0.05).For women who had pregnancy history,positive rate increased with the increase of the number of pregnancy (χ2 =235.846,P＜0.05),but the positive rate reduced with the increase of the time to the last pregnancy (χ2 =48.387,P＜ 0.05). Conclusions There was closely relationship between pregnancy and women's PLT antibody producing. From the 16th to 28th week of pregnancy,the positive rate of platelet antibody increased with the pregnant time increasing.When a woman with positive platelet antibody was pregnant again,the monitor changes of platelet antibody during the 16th to 28th week pregnancy could prognose the same immune thrombocytopenic purpura.Test the platelet antibody of women who have pregnancy history could effectively prevent the post-transfusion purpura, post-transfusion acute lung injury, platelet transfusion refractoriness,non-hemolytic febrile transfusion reactions and other transfusion reactions. Key words: platelet; antibody; pregnancy