Abstract
Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in human with significant mortality and morbidity. This study was designed to identify the circulating influenza virus in Ibadan, Nigeria during the 2006/2007 season. Throat swab samples were collected from patients presenting with acute respiratory tract infection at the Out-Patient Departments of major hospitals in Ibadan over a period of seven months from November 2006 to May 2007. Isolation of influenza virus was performed using Madin-Darby Canine Kidney cell line and 10 days old chicken embryonated egg. Isolates was identified by haemagglutination and haemagglutination-inhibition assays using selected CDC Influenza reference antisera (A, B, subtype H1 and H3). Out of 128 patients tested, 21(16.4%) yielded positive for virus isolation. Identification of the isolates showed that 19(14.8%) were positive for influenza virus out of which 11(8.6%) and 8(6.2%) were influenza A and B viruses respectively. Influenza A virus 6(4.7%) were subtype H1; 4(3.1%) were co-subtype H1 and H3; and 1(0.8%) was not inhibited by subtype H1 and H3. The circulation of influenza virus A and B in this study is important to contributing knowledge and data to influenza epidemiology and surveillance in Nigeria.
Highlights
Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in humans withAfrican Health SciencesThe pandemics of influenza are typically due to the emergence of ‘subtypes’ of influenza A viruses as influenza B and C viruses have not been known to cause pandemic in the past[7]
Influenza virus A (H1 and H3) and B co-circulation among patient presenting with acute respiratory tract infection in Ibadan, Nigeria
Fever, sputum production, cough, malaise, fatigue, runny nose and headache were common clinical manifestations observed in positive patients enrolled for the study
Summary
Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in humans withAfrican Health SciencesThe pandemics of influenza are typically due to the emergence of ‘subtypes’ of influenza A viruses as influenza B and C viruses have not been known to cause pandemic in the past[7]. Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in humans with. When a significant “antigenic” shift in at least one of the influenza A virus surface proteins haemagglutinin and neuraminidase occurs spontaneously, often there is no immunity to this new virus. This can lead to a pandemic if the virus achieved effective human to human transmission and replication causing serious illness. Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in human with significant mortality and morbidity. Influenza virus A (H1 and H3) and B co-circulation among patient presenting with acute respiratory tract infection in Ibadan, Nigeria.
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