Abstract

Influenza viruses cause a substantial burden of disease every year. 1 Goldstein E Viboud C Charu V Lipsitch M Improving the estimation of influenza-related mortality over a seasonal baseline. Epidemiology. 2012; 23: 829-838 Crossref PubMed Scopus (107) Google Scholar Vaccination is the main preventive measure, and is widely recommended. The UK is rolling out a universal childhood vaccination programme 2 Pebody RG Green HK Andrews N et al. Uptake and impact of a new live attenuated influenza vaccine programme in England: early results of a pilot in primary school-age children, 2013/14 influenza season. Eurosurveillance. 2014; 19: 20823 Crossref Scopus (71) Google Scholar that is predicted to have a substantial effect on influenza morbidity and mortality. 3 Baguelin M Flasche S Camacho A Demiris N Miller E Edmunds WJ Assessing optimal target populations for influenza vaccination programmes: an evidence synthesis and modelling study. PLoS Med. 2013; 10: e1001527 Crossref PubMed Scopus (185) Google Scholar Antiviral drugs are available for the treatment of infections, and the most commonly used is oseltamivir (Tamiflu). The effectiveness of oseltamivir has been the subject of much debate. 4 Jefferson T Doshi P Multisystem failure: the story of anti-influenza drugs. BMJ. 2014; 348: g2263 Crossref PubMed Scopus (48) Google Scholar Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trialsOur findings show that oseltamivir in adults with influenza accelerates time to clinical symptom alleviation, reduces risk of lower respiratory tract complications, and admittance to hospital, but increases the occurrence of nausea and vomiting. Full-Text PDF

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