Influenza A matrix protein M2 downregulates CFTR: inhibition of chloride transport by a proton channel of the viral envelope

Abstract

in a recent issue of the Journal , Londino et al. ([15][1]) report that the influenza matrix protein M2 decreases the activity of the human cystic fibrosis transmembrane conductance regulator (CFTR) by increasing secretory organelle pH, which results in downregulation of CFTR in a ubiquitination-