Influencing factors on chest CT characteristic changes in children with invasive pulmonary fungal infections

Abstract

Objective To analyze the characteristics of chest CT in children with invasive pulmonary fungal infections(IPFIs), and to explore the influencing factors on chest CT manifestations in children with IPFIs. Methods A retrospective case-control study was conducted to select 97 children with IPFIs from October 2010 to October 2016 in the department of respiratory medicine, PICU and hematology.The children were divided into CT characteristic change group(39 cases) and CT non-characteristic change group(58 cases) according to the chest CT manifestations. Non-conditional multivariate Logistic regression analysis was used to identify the independent influencing factors of CT characteristic changes in children with IPFIs. Results The ratios of less than 3-year-old infants, Candida, the proportion of ICU admission in the CT characteristic change group were lower than those in the CT non-characteristic change group(P<0.05). The proportions of more than 3-year-old, neutropenia, Aspergillus, central venous catheter, hematological malignancies were higher than those in the CT non-characteristic change group(P<0.05). Multivariate Logistic regression analysis showed that the hematological malignancies was an independent influencing factor for the characteristic changes of CT in children with IPFIs. Conclusion When children with blood system malignant tumors manifest as fever, cough and other symptoms of infection, chest CT manifestations show characteristic changes, Aspergillus infection should be considered, and empirical antifungal treatment should be focused. Key words: Invasive pulmonary fungal infection; Chest computed tomography; Influencing factor; Children