Influencing factors of thyroid disease in breast cancer patients

Abstract

Objective To understand the status and influencing factors of thyroid disease in breast cancer patients, and to identify the high-risk people with thyroid disease. Methods Breast cancer patients were continually collected from Jan 2016 to Mar 2016 in Shanxi Cancer Hospital. Age, surgery time, the state of thyroid disease, medical record, the general condition, immunohistochemistry and pathological findings, thyroid B-mode ultrasonography were investigated respectively. All cases were divided into two groups according to whether to suffer from thyroid disease or not. The influencing factors for thyroid disease in patients with breast cancer were screened. Logistic regression was used for univariate and multivariate analysis. Results A total of 293 cases (69.3%) suffered from thyroid disease in 423 breast cancer patients. The univariate analysis showed that prevalence rate of thyroid disease had statistical differences in age [ 0.05). Multivariate analysis showed that the risk factors were age (OR= 3.928, 95% CI= 1.819-8.482, P < 0.001) and ER++- ER+++ (OR= 1.696, 95% CI= 1.094-2.628, P= 0.018). Conclusion Age≥50 and ER++- ER+++ are the major influencing factors of thyroid disease for patients with breast cancer. Key words: Breast neoplasms; Thyroid diseases; Receptors, estrogen