Influencing factors of positive rate of transrectal ultrasound biopsy for prostate cancer

Abstract

Objectives To investigate the influencing factors of positive rate of transrectal ultrasound(TRUS) biopsy for prostate cancer. Methods A total of 222 male patients who underwent TRUS biopsy for prostate cancer were analysed retrospectively from June 2011 to June 2014. The relevant data including age, total prostate specific antigen(TPSA), magnetic resonance imaging(MRI), prostate volume(PV) and degital rectal examination(DRE) were analysed by univariate and multivariate regression and ROC. Then the PAMD(PV+ Age+ MRI+ DRE) scoring system was used to predict the positive rate of TRUS biopsy for prostate cancer. Results 88(39.6%) cases were diagnosed with prostate cancer among the 222 patients. Multivariate regression showed that age, TPSA, PV, MRI and DRE were all significant independent predictors of prostate cancer, with OR and 95%CI of 2.539(1.156~5.576), 2.745(1.677~4.494), 0.409(0.187~0.891), 0.132(0.039~0.446) and 0.018 (0.005~0.063) respectively. Patients with the risk score of ≥4 by PAMD scoring system had a significantly higher rate(48.2%) of prostate cancer than others risk score groups. Conclusions PAMD scoring system can help to increase the positive rate of TRUS biopsy for prostate cancer. Key words: Prostatic Neoplasms; Biopsy, Needle; Rectum