Influencing factors analysis on mammography versus ultrasonography in detecting early stage breast cancer and epidemiological characteristics by logistic regression

Abstract

Objective To evaluate the influencing factors of mammography versus ultrasonography in detecting early stage breast cancer and epidemiological characteristics. Methods A retrospective analysis was performed on stage T1 (tumor diameter ≤2 cm) and Tis (ductal carcinoma in situ) breast cancer confirmed by histopathology from July 2011 to July 2013, 959 patients (971 lesions) had mammography, ultrasonography, and epidemiological data. According to the BI-RADS, the lesions of BI-RADS categories 1, 2, 3, 4A were negative, the lesions of BI-RADS categories 4B, 4C, 5 were positive. A face to face interview questionnaire collected information regarding epidemiological data, including age, body mass index, age at menarche, age at first live birth, history of pregnancy, number of live births, history of lactation, history of abortion, and menopausal status. The χ2 test was used to compare the efficacy of mammography and ultrasound in detecting early stage breast cancer. Logistic regression was used to analyze the relative factors influencing the detection rate of two modalities. Results The detection rate of mammography and ultrasound was 90.1% (875/971) and 92.6% (899/971) respectively with statistical significance (χ2=150.34, P=0.000). Breast density, lesion types, age, and postmenopausal status were risk factors for the detection rate of early stage breast cancer on mammography, the odds ratios (OR) was 0.315, 6.669, 2.609, and 2.236 and the 95% CI was 0.136—0.731, 2.841—15.658, 1.681—4.048, and 1.453—3.439, respectively. Lesion types and age were risk factors for the detection rate of early stage breast cancer on ultrasonography, the OR was 0.204, 1.798, and 95%CI was 0.103—0.405, 1.107—2.920, respectively. More than patients with less than 50 years old showed only-calcification type breast cancer on mammography (OR=2.256, 95%CI:1.348—3.773) , women with lower number of live birth showed not only-calcification type breast cancer on mammography (OR=0.467, 95% CI:0.250—0.872) . Conclusion Breast density, age, postmenopausal status and lesion types were risk factors for epidemiological characteristics associated with detection rate of early stage breast cancer for mammography versus ultrasonography. Key words: Breast neoplasms; Mammography; Ultrasonography; Epidemiologic factors