Influencing factors analysis of microvascular invasion in patients with hepatocellular carcinoma

Abstract

Objective To evaluate the correlation between microvascular invasion(MVI ) and prognosis in patients with hepatocellular carcinoma (HCC), and to analyse the influencing factors of MVI in patients with HCC. Methods Total of 81 patients with hepatocellular carcinoma treated in Beijing Hospital from January 2014 to December 2016 were retrospectively studied. There were 65 males and 16 females. The mean age was 59.6±12.7 years, and the age ranged from 21 to 87 years old. Pathological examination showed presence of MVI in 35 patients. Results Total of seventy-six patients with hepatocellular carcinoma were followed-up. The 1-, 2-, 3- and 4-year overall survival rates in the 35 patients with microvascular invasion of hepatocellular carcinoma were 78.6%, 55.4%, 38.3%, and 32.2%, respectively. The 1-, 2-, 3-, and 4-year overall survival rates of the 41 patients without microvascular invasion were 93.4%, 76.5%, 68.2% and 68.2%, respectively. The difference was significant (P 0.05). Multivariate logistic regression analysis showed the maximum diameter of tumor >5 cm (OR=6.340, 95%CI: 2.000~20.096), preoperative total bilirubin (TBil)>17 μmol/L (OR=5.067, 95%CI: 1.386~18.525), and preoperative alpha-fetoprotein (AFP)>400 μg/L (OR=6.042, 95%CI: 1.435~25.444) were independent risk factors of microvascular invasion (P<0.05). Conclusion Hepatocellular carcinoma patients with microvascular invasion had poor prognosis. Preoperative AFP, preoperative TBil, and diameter of tumor were independent risk factors of microvascular invasion in patients with hepatocellular carcinoma. Key words: Carcinoma, hepatocellular; Prognosis; Microvascular invasion; Influencing factors