Influencing factorial analysis of the relapse of alcohol dependence

Abstract

Objective To investigate environmental factors of the relapse of alcohol dependence. Methods One hundred and seventeen in-patients with alcohol dependence were assessed with a home-designed questionnaire, Family Environment Scale Chinese Version (FES-CV), Clinic Institute Alcohol Withdrawal Syndrome Scale Chinese Version(CIWA-Ar) and the Scale of Personality Change Post-Traumatic Brain Injury(SPCPTBI). One hundred and five patients reassessed with alcohol dependence syndrome diagnostic criteria 1 year after hospitalization.t-test, chi-square and logistic regression were used for analysis. Results 57 of 105 were relapse and 48 of them were not relapse. The results showed that relapse group had a higher divorce or separated or remarried rate(21/36) than the no-relapse one (7/41) ( chi-square = 6.60, P=0.010); a less number of years of education(5.2±1.8 vs 7.2±1.7, t=5.64, P=0.000); a bigger daily drinking((512 ±186)ml vs (396 ±109)ml, t=3.93, P=0.000); a higher drinking frequency in relapse group((2.6±0.9) vs (1.8±0.6)times, t=5.38, P=0.000); a higher rates in personality change(47/57 vs 15/48), brain damages (27/57 vs 13/48) and mood disorders (35/57 vs 17/48), They also showed that relapse group had more problems on intimate degree (5.66±1.40 vs 6.20±1.20) , emotional expression (4.59±1.54 vs 5.41±1.26, independence(3.61±1.29 vs 4.64±1.49), organization(4.26±1.56 vs 5.22±1.18), and self-controlling(4.21±1.43 vs 5.12±1.12), the differences were significant (P<0.05); a higher contradiction score(4.35±1.73 vs 3.64±1.22, t=2.42, P=0.017). Logistic regression analysis showed that the number of daily drinking , intelligent damaged, emotional problems, and dependence were the risk factors for the alcoholic relapse(OR=7.44, 3.99, 3.92, 2.96); Self-controlling was the protective factors for the alcoholic relapse (OR=0.19). Conclusion Problem marital status, less education , and heavy drinking , and the number of drinking times, personality change, intellectual impairment and mood change, and poor family environment were the risk factors for the relapse of alcohol dependence. Key words: Alcohol dependence; Abstinence; Relapse rate; Risk factor