Influencing advance directive completion rates in non-terminally ill patients: a systematic review

Abstract

Purpose: To conduct a systematic review of educational advance care planning interventions directed at patients without terminal illness to determine their influence on the completion rate of advance directives (AD). Materials and Methods: We searched MEDLINE; Cochrane Library, and reference lists of all pertinent retrieved articles for randomized trials (RCTs), restricted to English language and adults ≥18 years. Two investigators independently and in duplicate determined trial eligibility. We included published RCTs evaluating an educational intervention comprised of at least one of; written, audio, or video materials, or direct counseling, and if an outcome included AD completion rate. Results: Nine RCTs (N=3,206) were included. Overall, methodologic quality and reporting transparency were poor. The median composite quality score was 5 (range, 0–10). The odds ratios for AD completion rates ranged from 0.41 to 106.0 across the trials (test of heterogeneity P < .001). The summary odds ratio for these educational interventions was 3.71 (95% C.I. 1.46, 9.40). Trials with greater methodologic rigor and reporting transparency produced a more conservative estimate of effect, 2.42 [0.96, 6.10] versus 28.69 [5.08, 162.06] for less rigorous and poorly reported trials ( P = .013). Conclusions: Advance directive completion rates documenting patient preferences for end-of-life care may be increased by simple patient-directed educational interventions.