Influencia de la inflamación crónica prostática en muestras de biopsia sextante en los niveles séricos de PSA total y PSA libre

Abstract

PurposeTo analyze the influence in total serum PSA (PSAt) and free PSA (PSAl) of chronic inflammatory patterns from prostate biopsy specimens of non-symptomatic patients. Patients and methods518 non-symptomatic patients underwent ultrasonography and prostatic biopsy for PSAt>4 ng/mL and/or DRE suspicious of malignancy. Those with a negative biopsy were divided into two subgroups: patients with benign prostatic lesions (LBP) and patients with chronic inflammatory signs (SIC). Results456 patients (88.03%) were biopsied for elevated PSAt or/and DRE suspicious of malignancy in 62 patients (11.97%). Mean volume in patients with LBP was 54cc, while 51cc was the mean volume in patients with histological pattern of chronic inflammatory infiltrate. Mean PSAt in patients with LBP was 9.43 (IC 95% ± 7.8) and 8.8 (IC 95% ± 5.73) in SIC’s group patients. ConclusionsThe presence of SIC has no significant influence in the eventual value of PSAl y PSAt in a selected population. As a result of that finding data from serum PSA can be reliably evaluated even in the presence of SIC in biopsy specimens.