Abstract
Background: To investigate the change of leptin levels after a total life style changes (diet, exercise induced weight loss and behaviors modification) and the possible association between leptin and total life style changes (TLC) in obese subjects. Materials & Methods: A total number of forty obese subjects (twenty patients of DM type 2 and twenty age and sex matched healthy obese controls) divided into two different group (twenty in each) were studied. After recording a detailed history, a complete physical examination was carried out. Fasting serum leptin levels estimated and both group total life style changes intervention (diet control and exercise induced weight loss and behaviors modification) was given and after duration of eight-week TLC intervention, all subjects were reexamined and fasting serum leptin levels were re-estimated. Results: Obese diabetic group shows significant reduction in leptin levels 3.15 ± 10.87 in comparison with obese nondiabetic group 1.77 ± 9.21. Conclusion: Total lifestyle changes intervention (diet control and exercise induced weight loss and behaviors modification) significantly reduces leptin levels and significantly reduces the anthropometrics values and biochemical values in obese type 2 diabetes mellitus in comparison with obese nondiabetic group.
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