Influences of oxytocin on serological parameters of obese and non-obese rats

Abstract

Oxytocin, a hormone synthesized in the hypothalamus and stored in the neurohypophysis, plays roles in uterine contraction and milk ejection, with receptors expressed in various organs, including the kidney and liver. This study assessed oxytocin's effects on these organs in obese and non-obese rats, using serum enzymes and biochemical parameters. Ninety-six rats were divided into four groups, receiving different treatments. Results showed significant reductions in urea, AST, AP, TP, albumin, and globulin in non-obese rats treated with oxytocin. In contrast, changes in TP, albumin, and globulin were observed in all groups. Creatinine, ALT, GGT, and CK levels showed no significant differences. These findings suggest that oxytocin may mitigate kidney and liver damage by suppressing inflammation and apoptosis, altering biomarker levels.