Abstract
Rationale: The hepatic immunity generally declines with aging. Clinically, the consequences of impaired hepatic immune function in the elderly include an increased susceptibility to infections. In the previous study, phagocytic function of Kupffer cells (resident hepatic macrophages) declines with aging. However, the influence of aging on expression of lipopolysaccharide (LPS) receptor’s expression of Kupffer cells is not clarified. Herein, we examined how the aging affects expression of LPS receptor (CD14) of Kupffer cells with mice model.
Published Version
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