Abstract
We have assessed the effect of age on basal renal ornithine decarboxylase (ODC) activity and on the response of this enzyme to streptozotocin-induced diabetes. Renal ODC activity was found to decline with age in both male and female rats. In addition, three distinct patterns of renal ODC activity were observed during the first three days of diabetes depending on the age of the rats. When expressed as a percentage of non-diabetic age-matched control animals, renal ODC activity was decreased in 23-25 day old male rats (24 ± 7 %), unchanged in the 30-35 day old (93 ± 11 %), and increased in rats older than 45 days (308 ± 9 %). These changes were similar in female rats.
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Schedule a callMore From: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
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