Abstract
Rotator cuff tears occur mainly due to overload of the tendons, which leads to a progressive degenerative process and to rotator cuff tears. Surgical treatment is indicated in more advanced stages of the lesion. Retear affects approximately 35% of patients. The goal of the present study was to investigate the effect of mononuclear cell transplantation in rotator cuff repairs in relation to patient functional recovery. Thirty patients with rotator cuff tear were divided into two groups and submitted to rotator cuff repair. In addition to the surgical procedure, the experimental group was submitted to transplantation of mononuclear bone marrow cells. One to two years post-op, both groups were submitted to evaluation of pain, amplitude of movement, retears, and isokinetic evaluation of flexion-extension movements, external and internal rotations, and abduction and adduction of the shoulder. The operated shoulder was compared to the healthy shoulder. Mann-Whitney test was used to evaluate the percentage improvement of the operated shoulder in relation to the healthy shoulder. SPSS (13.0) was used for statistical analyses; the level of significance was p<0.05. The control and the experimental groups presented near-normal values for the variables analyzed in the comparison between shoulders. However, the experimental group showed better results than the control group. Functional recovery of patients submitted to repair with mononuclear cell transplantation was different than that of controls: the incidence of retear was lower in the experimental group; also, the muscle torque and balance values were closer to the healthy shoulder values for the experimental group than the controls.
Highlights
Rotator cuff disease compromises the health status and functional independence of the elderly population [1]
The control group included patients submitted to rotator cuff repair without cell transplantation; the experimental group was submitted to repair with mononuclear bone marrow cell transplantation
The movement amplitude, muscle torque, and muscle imbalance increased for both groups when the operated shoulder values were compared to the healthy shoulder values (Table 2)
Summary
Rotator cuff disease compromises the health status and functional independence of the elderly population [1]. More advanced stages of the disease are treated surgically with rotator cuff repair [2]; the goal of the procedure is to recover shoulder function [3]. Rotator Cuff (RC) disease is one of the common causes of shoulder pain and loss of muscle strength [4]. Rotator cuff tears occur due to degenerative factors and micro traumas that damage the tendons at the point of insertion onto the humeral head [4]. The lesion begins with an inflammatory process; after, with repetitive stress, tendinosis and rotator cuff tears may follow [6]. Because it is a degenerative disease, the prevalence increases with age [1]
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