Abstract
Abstract The influence of laser radiation on human osteoarthrotically changed chondrocytes was investigated using various wavelengths, power density and dependence on the exposure time in order to confirm the positive results obtained in an animal experiment. It was manifested that, if there was a specific parameter constellation (2 W; 16 W/cm 2 ; 60 s; 120 J), an enhanced matrix synthesis (cartilage material from 36 patients) could be achieved. The proof succeeded by applying the radioisotope marking method ( 3 H-proline). Interestingly enough it turned out that the application of too high a power density but constant energy density resulted in a reduced matrix synthesis rate (reduction of 28%). In this study, it was demonstrated for the first time that laser radiation may have a positive influence on human cartilage thus contributing to future in-vivo application.
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