Abstract
Mice were given to drink sodium fluoride solutions of various concentrations and in various daily for a period of 220 days. At the end of experiment, both the fluoride content and the degree of fluorosis of the incisor teeth depended only upon the concentration of fluoride in the administered solutions. The total daily fluoride intake was without effect. Both the fluoride concentration in the drinking water and the total daily intake of fluoride produced effects in the tibiae even after 220 days of experiment. This was caused by a great proportion of the bone which was not available to fluoride exchange while the unavailable bone conserved the state existing earlier. The importance of these results for dental caries prevention is discussed. The administration of fluoride in the form of fluoridated drinking water appears to be most advantageous from this point of view.
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