Abstract
ABSTRACT Background: - Cardiovascular disease (CVD) is the most common group of non-communicable diseases that is responsible for major morbidity and mortality worldwide. Low levels of Vitamin D are associated with CVD risk factors and might predict the occurrence of cardiovascular events through its influence on the process of atherogenesis. Aim: - This study aimed to determine the association between vitamin D and some markers of atherogenesis in apparently healthy youths. Methods: - 150 young adults aged 18 to 25years were recruited from tertiary institutions in Ibadan, Nigeria in 2018 and were grouped into two based on their vitamin D status; Group A (vitamin D ≥30 ng/ml i.e. sufficient) and Group B (vitamin D < 30ng/ml i.e. insufficient/deficient). Anthropometric data, plasma Glucose, Total cholesterol (TC), High density lipoprotein-cholesterol (HDL-C), Triglycerides (TG), Low density lipoprotein-cholesterol (LDL-C); and serum Insulin, high sensitive C-reactive protein (hsCRP), Apolipoprotein B (Apo B), Apolipoprotein A1 (ApoA1), ApoB/ApoA1 ratio, Lipoprotein (a) [Lp (a)] were determined by standard methods and compared in the two groups. Results:- Statistical analysis was performed using SPSS version 20.0. Students t test and Pearson correlation were used to compare and assess relationship between normally distributed variables, while Mann-Whitney U test and Spearman rank correlation were used for non-Gaussian variables respectively. Results showed that there was no significant statistical difference in the compared variables between the two groups, except HDL-C which is significantly lower in vitamin D deficient group compared to vitamin D sufficient group. The vitamin D sufficient participants were also taller than the deficient/insufficient group. There was a weak positive correlation between vitamin D and HDL-C; and a weak negative correlation between vitamin D and hs-CRP in vitamin D sufficient group. Conclusion: - Vitamin D insufficiency or deficiency might be associated with the development and progression of inflammation, and abnormal lipid profile (decreased HDL-C); both of which are important risk factors in the development of CVDs.
Published Version
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