Abstract
SummaryVit B12 or liver extract administered to force-fed rats on constant food intake induced neither weight gain nor N retention. When vit B12 was administered to force-fed rats on constant food intake, made hyperthyroid by injection of thyroxine, the weight loss was identical with that of hyperthyroid animals not receiving vit B12. The N loss resulting from the catabolic action of thyroxine, however, was significantly smaller in thyroxine-treated rats receiving B12 than in the thyroxine-treated controls. Liver extract had a, similar action, but the values obtained were statistically not significant. These results suggest that in hyperthyroid rats vit B12 spares protein at the expense of other body constituents.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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