Abstract
The rectal absorption of acetaminophen from an aqueous solution and from several polyethylene glycol base dosage forms was studied in six human subjects using urinary excretion measurements. A relationship was observed between acetaminophen bioavailability and the dielectric properties of the vehicles utilized. The in vitro dissolution rates of acetaminophen in these dosage forms were also studied and were somewhat related to the time of occurrence of the maximum urinary excretion rate.
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