Abstract
The significant place in the menopausal syndrome and deficiency of estrogens takes psycho-emotional disorders. Psychosomatic disorders, difficulty of adequate evaluation and correction in menopausal women evidence the fact that this issue is important today. Severe symptoms of menopausal syndrome at violation of psycho-vegetative sphere appear in the early post-menopause, due to final termination of ovarian function and sharply deficiency of estrogens during this period. Intravaginal administration of glucosamine hydrochloride to spay female rats has moderate anti-depressant and anxiolytic effects, accompanied by reduction of the psycho-emotional behavioral reactions, normalization of locomotor activity of animals. As of totality of effects, the estriol reference drug is better than glucosamine hydrochloride. The data reveal prospects of vaginal gel glucosamine hydrochloride in the treatment of menopausal disorders of various origins.
Highlights
With increase in life expectancy and the proportion of elderly women in the population, the preservation of their life quality has become a pressing medical and social issue of today
According to researchers, who have studied the clinical manifestations of climacteric in women of 45–54 years, with climacteric syndrome lasting within 5 years, 78.4 % of cases show disorders of psycho-emotional sphere [1,2,3]. 10 % of women experience depression, which is one of the most severe and difficult-to-treat symptoms, and 13 % – neurotic disorders, showing themselves in tearfulness, irritability, seizures, feeling of fear, anxiety, sleep disorders [4,5,6,7,8,9]
The goal of this study is the study of glucosamine hydrochloride effect to psycho-emotional and locomotor activity of spay female rats at intravaginal administration
Summary
With increase in life expectancy and the proportion of elderly women in the population, the preservation of their life quality has become a pressing medical and social issue of today. Climacteric is a physiological period, which includes a natural ovarian failure, reduced estrogen level, which in its turn results in development of vasomotor, urogenital, endocrine-metabolic and psycho-emotional disorders. According to researchers, who have studied the clinical manifestations of climacteric in women of 45–54 years, with climacteric syndrome lasting within 5 years, 78.4 % of cases show disorders of psycho-emotional sphere [1,2,3]. The use of drugs of metabolite-tropic action, which include glucosamine hydrochloride, can be considered as a new approach to prevention and treatment of hypo-estrogenicdisorders. Experimental studies of recent years have shown, that glucosamine hydrochloride,atoral administration to animals, increases synthesis of endogenous estrogen, and has neuroprotective and anxiolytic (2016), «EUREKA: Health Sciences» Number 2 activity [12]. Researches of vaginal pharmaceutical forms of glucosamine hydrochloride have not been carried out yet
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