Influence of vaccination status and clinical, seasonal and sociodemographic factors on rotavirus prevalence in KwaZulu-Natal, South Africa

Osaretin E Asowata,Olubisi T Ashiru,Prashini Moodley,A Willem Sturm,Saajida Mahomed

doi:10.1080/23120053.2018.1551850

Osaretin E Asowata, Olubisi T Ashiru + Show 3 more

Open Access

https://doi.org/10.1080/23120053.2018.1551850

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Abstract

Human rotavirus infection is the leading cause of diarrhoea in infants and young children worldwide. In South Africa, diarrhoea is a major cause of childhood morbidity and mortality in children les...

Highlights

IntroductionRotavirus belongs to the family of Reoviridae
Rotavirus belongs to the family of Reoviridae.1 This family includes 12 genera, of which rotavirus is the most clinically significant and is the leading cause of acute infantile diarrhoea worldwide.1 Approximately 576,000 diarrhoeal deaths are recorded worldwide among children less than five years old annually and rotavirus accounts for 215,000 (37.3%) of these deaths.2 About 50% of these rotavirus infections occur in developing countries.2 In South Africa, diarrhoeal diseases are ranked as the third cause of childhood mortality in children less than five years of age.3 Rotavirus has been documented as causing one-third of all admissions to hospital for diarrhoea prior to the introduction of the rotavirus vaccine
The prevalence of rotavirus infection among the under two years and above two years age group was significantly different in the univariate but not in the multivariate analysis

Summary

Introduction

Rotavirus belongs to the family of Reoviridae.. Rotavirus belongs to the family of Reoviridae.1 This family includes 12 genera, of which rotavirus is the most clinically significant and is the leading cause of acute infantile diarrhoea worldwide.. 576,000 diarrhoeal deaths are recorded worldwide among children less than five years old annually and rotavirus accounts for 215,000 (37.3%) of these deaths.. About 50% of these rotavirus infections occur in developing countries.. In South Africa, diarrhoeal diseases are ranked as the third cause of childhood mortality in children less than five years of age.. Rotavirus has been documented as causing one-third of all admissions to hospital for diarrhoea prior to the introduction of the rotavirus vaccine.

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